The new performance will be hosted by the Zappos Theater at Planet Hollywood Resort & Casino, beginning December 6.
Tickets for the upcoming show go on sale this Friday (June 21).
In addition to being the star onstage, Twain will serve as the show's creative director.
"I'm actually going to put a dance floor on the stage so there'll be some fun audience participation," she said in a statement.
"Let's Go" will mark the singer's second stint in Vegas. Her first residency ran from 2012 to 2014.
The news is out!! I'm returning to Vegas this December, for my new residency 'Let's Go' at @ZapposTheater! Tickets go on sale this Friday at 10am PT. I am SO excited for this show, and can't wait to see you all there ❤️ https://t.co/lzxVzpbYFH pic.twitter.com/tdmcgWGrXs— Shania Twain (@ShaniaTwain) June 17, 2019